Description

3-(4-Ethynylphenyl)Prop-2-Enal is a high-value, multi-functional organic building block featuring both an ethynyl and an α,β-unsaturated aldehyde moiety. This unique molecular structure makes it a critical intermediate for advanced organic synthesis, particularly in the development of novel pharmaceuticals, agrochemicals, and functional materials. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted small molecule drugs, kinase inhibitors, and other bioactive compounds.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and plant growth regulators.
• Material Science Building Block: Essential for creating conjugated polymers, organic semiconductors, and advanced OLED (Organic Light-Emitting Diode) materials.
• Cross-Coupling Reactions: Serves as a versatile substrate in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions.
• Click Chemistry: The ethynyl group enables efficient Huisgen 1,3-dipolar cycloaddition (click chemistry) for bioconjugation and polymer functionalization.
• Ligand and Catalyst Development: Used to synthesize novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-(4-Ethynylphenyl)Prop-2-Enal
CAS No.	2229670-34-0
Molecular Formula	C11H8O
Molecular Weight	156.18 g/mol
Synonyms	4-Ethynylcinnamaldehyde; (E)-3-(4-Ethynylphenyl)acrylaldehyde; 3-(4-Ethynylphenyl)acrylaldehyde; 2-Propenal, 3-(4-ethynylphenyl)-; p-Ethynylcinnamaldehyde; 4-Ethynyl-trans-cinnamaldehyde; 3-(4-Ethynylphenyl)-2-propenal
EINECS	Contact for details

Quality Control

Our 3-(4-Ethynylphenyl)Prop-2-Enal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown solid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.