Description

Cyclopropanecarboxylic Acid, 2,2-Difluoro-1-[4-(1-Methylethyl)Phenyl]- is a high-value, fluorinated cyclopropane derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a difluorocyclopropane ring and an isopropylphenyl moiety, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active ingredients, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the metabolically stable difluorocyclopropane motif.
• Agrochemical Synthesis: Used in creating advanced active ingredients for crop protection products, where the fluorinated cyclopropane structure can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where the rigid cyclopropane core and fluorine atoms can influence material properties.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological mechanisms and interactions.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on a commercial scale.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2,2-Difluoro-1-[4-(1-Methylethyl)Phenyl]-
CAS No.	2229454-39-9
Molecular Formula	C13H14F2O2
Molecular Weight	240.25 g/mol
Synonyms	2,2-Difluoro-1-(4-isopropylphenyl)cyclopropanecarboxylic Acid; 1-(4-Isopropylphenyl)-2,2-difluorocyclopropanecarboxylic Acid; α,α-Difluoro-4-isopropylbenzenecyclopropaneacetic Acid; 2,2-Difluoro-1-(p-isopropylphenyl)cyclopropanecarboxylic Acid; 4-(1-Methylethyl)benzenepropanoic acid, α,α-difluoro-β,β-dimethyl-; Difluorocyclopropane Isopropylphenyl Carboxylic Acid
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2,2-Difluoro-1-[4-(1-Methylethyl)Phenyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP (Good Manufacturing Practice) and non-GMP research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.