Description

1-([1,1'-Biphenyl]-4-Yl)-2,2-Difluorocyclopropane-1-Carboxylic Acid is a high-value, multifunctional fluorinated cyclopropane derivative. This compound is significant for its role as a key synthetic intermediate in advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation pesticides and herbicides, where the difluorocyclopropane moiety can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Acts as a core structure for creating advanced functional materials used in electronic displays and optoelectronic devices.
• Ligand & Catalyst Development: Employed in organometallic chemistry for the design of new chiral ligands and catalysts for asymmetric synthesis.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and the unique properties imparted by fluorine atoms in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	1-([1,1'-Biphenyl]-4-Yl)-2,2-Difluorocyclopropane-1-Carboxylic Acid
CAS No.	2229453-29-4
Molecular Formula	C₁₇H₁₂F₂O₂
Molecular Weight	286.27 g/mol
Synonyms	4-(2,2-Difluorocyclopropyl-1-carbonyl)biphenyl; [1,1'-Biphenyl]-4-carboxylic acid, 4-(2,2-difluorocyclopropyl)-; 1-([1,1'-Biphenyl]-4-yl)-2,2-difluorocyclopropanecarboxylic acid; 2,2-Difluoro-1-(4-phenylphenyl)cyclopropane-1-carboxylic acid; 4-(2,2-Difluorocyclopropane-1-carbonyl)-1,1'-biphenyl; Difluorocyclopropane biphenyl carboxylic acid; Biphenyl difluorocyclopropanecarboxylate
EINECS	Contact for details

Quality Control

Our 1-([1,1'-Biphenyl]-4-Yl)-2,2-Difluorocyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.