Description

1-(4-Chloro-2-Hydroxyphenyl)-2,2,2-Trifluoroethanone is a high-purity trifluoromethyl ketone derivative, a key building block in advanced organic synthesis. Its unique structure, featuring both a phenolic hydroxyl and a reactive trifluoroacetyl group, makes it a versatile intermediate for creating complex molecules with enhanced properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to incorporate trifluoromethyl motifs into new active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, anti-inflammatory, and anti-infective therapies.
• Agrochemical Synthesis: Serves as a precursor for synthesizing advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its ability to influence electronic properties and intermolecular interactions.
• Chemical Biology & Proteomics: Acts as a reactive handle or affinity tag in probe design for studying enzyme activity and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	1-(4-Chloro-2-Hydroxyphenyl)-2,2,2-Trifluoroethanone
CAS No.	2229260-52-8
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	4'-Chloro-2'-hydroxy-2,2,2-trifluoroacetophenone; 2,2,2-Trifluoro-1-(4-chloro-2-hydroxyphenyl)ethanone; 1-(4-Chloro-2-hydroxyphenyl)-2,2,2-trifluoroethan-1-one; 4-Chloro-2-hydroxy-α,α,α-trifluoroacetophenone; 2-Hydroxy-4-chloro-α,α,α-trifluoroacetophenone; TFAP-CI-OH (common abbreviation)
EINECS	Contact for details

Quality Control

Our production of 1-(4-Chloro-2-Hydroxyphenyl)-2,2,2-Trifluoroethanone adheres to strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure consistency and meet the exacting standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.