Description

1-(2,6-Dimethoxyphenyl)-2,2-Difluorocyclopropane-1-Carboxylic Acid is a high-value, multifunctional fluorinated cyclopropane building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluorocyclopropane scaffold imparts desirable metabolic stability and lipophilicity. It is primarily utilized in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological and physical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used as a precursor for novel herbicides, fungicides, and insecticides, leveraging the fluorinated cyclopropane moiety to improve efficacy and environmental profile.
• Advanced Material Chemistry: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorine-containing motifs.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: An essential raw material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	1-(2,6-Dimethoxyphenyl)-2,2-Difluorocyclopropane-1-Carboxylic Acid
CAS No.	2229219-47-8
Molecular Formula	C₁₂H₁₂F₂O₄
Molecular Weight	258.22 g/mol
Synonyms	2,2-Difluoro-1-(2,6-dimethoxyphenyl)cyclopropane-1-carboxylic acid; 1-(2,6-Dimethoxyphenyl)-2,2-difluorocyclopropanecarboxylic acid; Difluorocyclopropane carboxylic acid derivative; 2,2-Difluorocyclopropane-1-carboxylic acid, 1-(2,6-dimethoxyphenyl)-; Aryl difluorocyclopropane carboxylate
EINECS	Contact for details

Quality Control

Our production of 1-(2,6-Dimethoxyphenyl)-2,2-Difluorocyclopropane-1-Carboxylic Acid adheres to stringent quality management systems to ensure batch-to-batch consistency and reliability. The material is manufactured under GMP-like conditions suitable for pharmaceutical research and is supported by comprehensive analytical documentation. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles as per client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.