Description

Trifluoroacetic Acid CAS NO 2227206-76-8 is a highly versatile and potent fluorinated organic acid. It serves as a critical reagent and solvent in advanced organic synthesis and pharmaceutical manufacturing, valued for its strong acidity and excellent solvating properties. This compound is essential for industries requiring high-purity intermediates, including pharmaceutical development, agrochemical production, and specialty polymer synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for deprotection in peptide synthesis and as a solvent for HPLC.
• Agrochemical Manufacturing: Used in the synthesis of advanced fluorinated pesticides and herbicides.
• Organic Synthesis & Catalysis: Employed as a strong acid catalyst and solvent for various reactions, including esterifications and rearrangements.
• Polymer & Resin Production: Acts as a modifier and solvent in the production of specialty fluoropolymers.
• Analytical Chemistry: Utilized as a mobile phase modifier in liquid chromatography-mass spectrometry (LC-MS).
• Chemical Research & Development: A fundamental building block for introducing the trifluoromethyl group into complex molecules.

Basic Information

Product Name	Trifluoroacetic Acid
CAS No.	2227206-76-8
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; TFA; Perfluoroacetic Acid; 2,2,2-Trifluoroacetic Acid; CF3COOH; Trifluoroacetic Acid Anhydride (common misnomer); Kyselina trifluoroctova; Acide trifluoroacetique
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including assay, impurity profiling, and identity confirmation, to ensure it meets the high standards required for industrial and research applications. Certificates of Analysis (COA) documenting purity, physical properties, and safety data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile and hygroscopic nature, containers should be kept tightly sealed and under appropriate conditions (typically 15-25°C) to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.285 - 1.290
Density (20°C)	1.48 - 1.50 g/mL
Boiling Point	71 - 73 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.