Description

Boronic Acid, B-[1-(1-Ethoxyethyl)-1H-Pyrazol-4-Yl]- is a specialized organoboron compound featuring a pyrazole core functionalized with an ethoxyethyl protecting group. This molecular architecture makes it a valuable high-purity building block for advanced synthesis, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry and fine chemical manufacturing.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic acid coupling partner for constructing biaryl and heterobiaryl structures central to many active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the synthesis of complex drug candidates, especially those targeting kinases and other enzymes where the pyrazole moiety is a critical pharmacophore.
• Agrochemical Research: Employed in the development of novel herbicides and fungicides that utilize aryl-pyrazole chemistry.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the creation of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to develop activity-based probes and sensors for studying biological processes.
• Process Chemistry Development: Used for scaling up synthetic routes under GMP or non-GMP conditions for clinical trial material production.

Basic Information

Product Name	Boronic Acid, B-[1-(1-Ethoxyethyl)-1H-Pyrazol-4-Yl]-
CAS No.	2227194-01-4
Molecular Formula	C8H13BN2O3
Molecular Weight	196.01 g/mol
Synonyms	1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (Pinacol ester precursor); 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(1-ethoxyethyl)-1H-pyrazole; [1-(1-Ethoxyethyl)-1H-pyrazol-4-yl]boronic acid; B-[1-(1-Ethoxyethyl)-1H-Pyrazol-4-Yl]Boronic Acid; 1H-Pyrazole-4-boronic acid, 1-(1-ethoxyethyl)-; (1-(1-Ethoxyethyl)-1H-pyrazol-4-yl)boronic acid
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-[1-(1-Ethoxyethyl)-1H-Pyrazol-4-Yl]- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and hydrolysis. This compound is hygroscopic and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.