Description

1-Bromo-3-Chloro-4-Fluoro-2-Iodobenzene is a highly functionalized, multi-halogenated aromatic building block of significant synthetic utility. Its precise substitution pattern makes it a critical intermediate for constructing complex molecules in advanced research and development. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for use in cross-coupling reactions, ligand synthesis, and the development of novel active ingredients. Its unique halogen array allows for selective, sequential functionalization, enabling the efficient synthesis of sophisticated target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the halogen pattern can influence bioactivity and environmental fate.
• Material Science: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Employed in Suzuki, Stille, and Sonogashira cross-coupling reactions to introduce a highly substituted phenyl ring into complex molecular architectures.
• Ligand & Catalyst Development: Utilized for synthesizing novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Life Sciences & Diagnostics: Acts as a derivatization agent or a core structure for fluorescent probes and other diagnostic tools.

Basic Information

Product Name	1-Bromo-3-Chloro-4-Fluoro-2-Iodobenzene
CAS No.	2226439-58-1
Molecular Formula	C6H2BrClFI
Molecular Weight	335.34 g/mol
Synonyms	2-Iodo-1-bromo-3-chloro-4-fluorobenzene; 3-Chloro-4-fluoro-2-iodo-1-bromobenzene; Benzene, 1-bromo-3-chloro-4-fluoro-2-iodo-; 1-Bromo-3-chloro-4-fluoro-2-iodobenzene; 4-Fluoro-2-iodo-1-bromo-3-chlorobenzene; 2-Bromo-6-chloro-3-fluoro-1-iodobenzene (alternative numbering); BCFI-Benzene (abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-3-Chloro-4-Fluoro-2-Iodobenzene is manufactured and analyzed under strict quality management systems. We guarantee high batch-to-batch consistency and purity to meet the exacting standards of research and process development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.