Description

6-Methyl-5-Bromopyridine-3-Boronic Acid is a high-value, multi-functional heterocyclic boronic acid building block. This compound is essential for modern synthetic chemistry, enabling the rapid construction of complex molecular architectures through efficient cross-coupling reactions. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

This versatile boronic acid pinacol ester serves as a critical intermediate in various advanced chemical syntheses. Its primary applications include:

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for creating novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs and charge-transport materials.
• Chemical Biology & Proteomics: Serves as a handle for bioconjugation and the development of chemical probes and activity-based protein profiling (ABPP) reagents.
• Ligand Synthesis: Acts as a precursor for creating sophisticated chiral and achiral ligands used in catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	6-Methyl-5-Bromopyridine-3-Boronic Acid
CAS No.	2225178-09-4
Molecular Formula	C6H7BBrNO2
Molecular Weight	215.84 g/mol
Synonyms	(6-Methyl-5-bromopyridin-3-yl)boronic acid; 5-Bromo-6-methylpyridine-3-boronic acid; 3-Borono-5-bromo-6-methylpyridine; 5-Bromo-6-methyl-3-pyridineboronic acid; 6-Methyl-5-bromo-3-pyridinylboronic acid; 2225178-09-4; 6-Methyl-5-bromopyridine-3-boronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Our 6-Methyl-5-Bromopyridine-3-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance in critical cross-coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.