Description

6-Cyclopropyl-5-Trifluoromethylpyridine-3-Boronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile chemical building block. Its core value lies in enabling the synthesis of complex molecules through efficient Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality boronic acid derivatives for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the unique properties of the cyclopropyl and trifluoromethyl groups.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form new carbon-carbon bonds, facilitating the construction of complex biaryl and heterobiaryl structures.
• Chemical Library Development: Utilized in medicinal chemistry for the parallel synthesis and diversification of compound libraries to explore new chemical space.
• Ligand and Catalyst Preparation: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts.

Basic Information

Product Name	6-Cyclopropyl-5-Trifluoromethylpyridine-3-Boronic Acid
CAS No.	2225173-40-8
Molecular Formula	C9H9BF3NO2
Molecular Weight	231.0 g/mol
Synonyms	5-Trifluoromethyl-6-cyclopropylpyridine-3-boronic acid; (6-Cyclopropyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid; 3-Pyridineboronic acid, 6-cyclopropyl-5-(trifluoromethyl)-; 6-Cyclopropyl-5-trifluoromethyl-3-pyridinylboronic acid; Boronic acid, B-[6-cyclopropyl-5-(trifluoromethyl)-3-pyridinyl]-; CAS 2225173-40-8
EINECS	Contact for details

Quality Control

Our 6-Cyclopropyl-5-Trifluoromethylpyridine-3-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in critical applications like Suzuki coupling. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.