Description

2-(4-Cyclopropyl-3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound matters because it enables precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing cyclopropyl and fluorophenyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl-cyclopropyl structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: A reliable reagent for Suzuki-Miyaura cross-coupling to form biaryl and other conjugated systems under mild conditions.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for diagnostic and biochemical research.
• Process Chemistry: Employed in route scouting and scale-up for the efficient, large-scale production of fine chemicals.

Basic Information

Product Name	2-(4-Cyclopropyl-3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2223054-58-6
Molecular Formula	C15H20BFO2
Molecular Weight	262.13 g/mol
Synonyms	4-Cyclopropyl-3-fluorobenzeneboronic acid pinacol ester; (4-Cyclopropyl-3-fluorophenyl)boronic acid pinacol ester; 3-Fluoro-4-cyclopropylbenzeneboronic acid pinacol ester; 2-(3-Fluoro-4-cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (4-cyclopropyl-3-fluorophenyl)boronate; B-(4-Cyclopropyl-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(4-Cyclopropyl-3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee reproducible performance in your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.