Description

1-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Chlorophenyl]Pyrrolidin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a unique boronic ester-protected functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: The tetramethyl dioxaborolane (pinacol boronic ester) group serves as a stable, protected precursor for boronic acids, facilitating efficient palladium-catalyzed carbon-carbon bond formation.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Organic Synthesis: Employed in academic and industrial R&D labs for constructing complex heterocyclic and aromatic frameworks.
• Agrochemical Development: Potential intermediate in the synthesis of novel pesticides and herbicides requiring specific chlorophenyl and lactam motifs.
• Material Science Precursor: Can be utilized in the development of organic electronic materials and functional polymers.

Basic Information

Product Name	1-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Chlorophenyl]Pyrrolidin-2-One
CAS No.	2223054-05-3
Molecular Formula	C16H21BClNO3
Molecular Weight	321.60 g/mol
Synonyms	3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylpyrrolidin-2-one; 1-[3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidin-2-one; 2-Pyrrolidinone, 1-[3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 3-Chloro-4-(pinacolboryl)phenylpyrrolidin-2-one; CAS 2223054-05-3; BCPPO; Chlorophenyl Pinacol Boronate Pyrrolidinone.
EINECS	Contact for details

Quality Control

Our production of 1-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Chlorophenyl]Pyrrolidin-2-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.