Description

2-Chloro-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to construct pyrimidine-based herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Material Science Research: Serves as a monomer or functional unit in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.
• Catalyst Ligand Development: Acts as a starting material for creating novel bidentate or monodentate ligands in transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-scale API development.

Basic Information

Product Name	2-Chloro-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine
CAS No.	2223052-31-9
Molecular Formula	C11H16BClN2O2
Molecular Weight	254.52 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-4-methylpyrimidine; 2-Chloro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Chloro-4-methylpyrimidine-5-boronic acid pinacol ester; (2-Chloro-4-methylpyrimidin-5-yl)boronic acid pinacol ester; CAS 2223052-31-9
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Every batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all analytical results are available upon request, providing full traceability and batch-to-batch consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.