Description

5-Cyclopropyl-2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) for new drug candidates, particularly in kinase inhibitor and CNS-targeted therapies.
• Agrochemical Research: Used to construct novel heterocyclic compounds for the development of next-generation herbicides, fungicides, and insecticides.
• Material Science: Building block for creating organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Chemical Synthesis: Enables efficient C-C bond formation via palladium-catalyzed Suzuki-Miyaura cross-coupling reactions in complex molecule assembly.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Life Science Research: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.

Basic Information

Product Name	5-Cyclopropyl-2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	2223051-97-4
Molecular Formula	C14H19BFNO2
Molecular Weight	263.12 g/mol
Synonyms	5-Cyclopropyl-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Fluoro-5-cyclopropyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Boronic acid, 5-cyclopropyl-2-fluoropyridine-, 1,3,2-dioxaborolane ester; 5-Cyclopropyl-2-fluoro-3-pyridineboronic acid pinacol ester; (5-Cyclopropyl-2-fluoropyridin-3-yl)boronic acid pinacol ester; 2223051-97-4; 5-Cyclopropyl-2-fluoro-3-(pinacolatoboryl)pyridine
EINECS	Contact for details

Quality Control

Our 5-Cyclopropyl-2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for prolonged use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.