Description

3-Bromo-2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and CNS drug discovery.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based scaffolds.
• Material Science & OLED Development: Serves as a precursor for creating electron-transport materials, ligands for metal-organic frameworks (MOFs), and complex organic semiconductors.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile boronic ester coupling partner with aryl/heteroaryl halides to form biaryl and heterobiaryl linkages.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Ligand Synthesis for Catalysis: Intermediate for preparing sophisticated bidentate or tridentate ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	3-Bromo-2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	2223051-53-2
Molecular Formula	C₁₂H₁₇BBrNO₂
Molecular Weight	298.99 g/mol
Synonyms	2-Methyl-3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-bromo-2-methylpyridine; 3-Bromo-2-methylpyridine-5-boronic acid pinacol ester; (3-Bromo-2-methylpyridin-5-yl)boronic acid pinacol ester; 2-Methyl-3-bromo-5-pyridineboronic acid pinacol ester; 2223051-53-2; 3-Bromo-2-methyl-5-(pinacolboron)pyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency suitable for demanding research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.