Description

3-Bromo-2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of halogen and boronic ester functional groups, enabling precise, sequential cross-coupling reactions like Suzuki-Miyaura. This compound is critically needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel active ingredients, agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to construct novel pyridine-based scaffolds for next-generation herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Cross-Coupling Reactions: The pinacol boronate ester group facilitates efficient Suzuki-Miyaura couplings, while the bromo and chloro substituents allow for sequential, site-selective functionalization.
• Ligand and Catalyst Development: Employed in the preparation of novel bidentate and tridentate ligands for catalytic systems.
• Chemical Biology Probes: Useful for synthesizing tagged molecules for proteomics and target identification studies.

Basic Information

Product Name	3-Bromo-2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	2223049-72-5
Molecular Formula	C11H14BBrClNO2
Molecular Weight	332.40 g/mol
Synonyms	3-Bromo-2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Chloro-3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(3-Bromo-2-chloropyridin-5-yl)-2,2-dimethyl-1,3,2-dioxaborinane; 3-Bromo-2-chloro-5-pyridineboronic acid pinacol ester; (3-Bromo-2-chloropyridin-5-yl)boronic acid pinacol ester; Pinacol (3-bromo-2-chloro-5-pyridyl)boronate; CAS 2223049-72-5
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place (recommended 2-8°C for long-term stability). This material is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.