Description

2-tert-Butoxy-Pyrimidine-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for facilitating efficient cross-coupling reactions, enabling the rapid construction of complex molecular architectures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl and heteroaryl compounds.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Proteomics: Useful for synthesizing molecular probes and tool compounds for target identification and validation.
• Library Synthesis for Drug Discovery: Enables the efficient parallel synthesis of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	2-tert-Butoxy-Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	2223044-16-2
Molecular Formula	C14H23BN2O3
Molecular Weight	278.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(tert-butoxy)pyrimidine; 2-(tert-Butoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-tert-Butoxypyrimidine-5-boronic acid pinacol ester; 2-(tert-Butoxy)pyrimidine-5-boronic acid pinacol ester; 2-tert-Butoxy-5-pyrimidineboronic acid pinacol ester; 2-t-Butoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; Pyrimidine-5-boronic acid, 2-(1,1-dimethylethoxy)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-tert-Butoxy-Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.