Description

2-Methyl-6-Trifluoromethylpyridine-3-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern cross-coupling reactions, such as the Suzuki-Miyaura reaction. Its trifluoromethyl and pyridine motifs make it a critical intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylpyridine core for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine and nitrogen-containing heterocycle contribute to efficacy and environmental profile.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester partner for forming carbon-carbon bonds with aryl/heteroaryl halides, enabling rapid scaffold diversification.
• Chemical Biology & Medicinal Chemistry: Facilitates the discovery of new drug candidates through high-throughput screening and library synthesis.
• Custom Synthesis & Contract Manufacturing: A crucial reagent for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	2-Methyl-6-Trifluoromethylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	2223041-89-0
Molecular Formula	C13H15BF3NO2
Molecular Weight	285.07 g/mol
Synonyms	2-Methyl-6-(trifluoromethyl)pyridine-3-boronic acid pinacol ester; (2-Methyl-6-(trifluoromethyl)pyridin-3-yl)boronic acid pinacol ester; 3-Boronic acid, 2-methyl-6-(trifluoromethyl)pyridine-, pinacol ester; 2-Methyl-6-trifluoromethyl-3-pyridineboronic acid pinacol ester; 6-Trifluoromethyl-2-methylpyridine-3-boronic acid pinacol ester; Pinacol [2-methyl-6-(trifluoromethyl)pyridin-3-yl]boronate; Boronic acid, B-[2-methyl-6-(trifluoromethyl)-3-pyridinyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Methyl-6-Trifluoromethylpyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.