Description

2-(2-Cyclopropyl-6-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical advanced intermediate in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides containing cyclopropyl and fluorophenyl motifs.
• Material Science Research: Precursor for creating organic electronic materials and liquid crystals via palladium-catalyzed coupling.
• Chemical Biology Probes: Enables the labeling and modification of biomolecules for diagnostic and research applications.
• Library Synthesis: Facilitates high-throughput parallel synthesis for medicinal chemistry and hit-to-lead optimization.
• Catalyst Ligand Development: Serves as a precursor for synthesizing novel bidentate ligands for transition metal catalysis.

Basic Information

Product Name	2-(2-Cyclopropyl-6-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2223040-74-0
Molecular Formula	C15H20BFO2
Molecular Weight	262.13 g/mol
Synonyms	2-(2-Cyclopropyl-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Cyclopropyl-6-fluorophenyl)boronic acid pinacol ester; 2-Cyclopropyl-6-fluorobenzeneboronic acid pinacol ester; 2-Fluoro-6-cyclopropylbenzeneboronic acid pinacol ester; 2-Cyclopropyl-6-fluorophenylboronic acid pinacol ester; Pinacol (2-cyclopropyl-6-fluorophenyl)boronate; 2-(2-Cyclopropyl-6-fluorophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(2-Cyclopropyl-6-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.