Description

5-Methyl-6-Cyclopropylpyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, such as Suzuki-Miyaura couplings, which are fundamental for constructing complex molecules in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug discovery programs targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the cyclopropyl and pyridine motifs for bioactivity.
• Material Science Research: Serves as a precursor for creating functional organic materials, including ligands for catalysts, organic semiconductors, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester group makes it a stable and highly reactive partner for palladium-catalyzed C-C bond formation with aryl/heteroaryl halides.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening to generate diverse compound libraries for biological evaluation.
• Ligand and Catalyst Design: The pyridine nitrogen and unique substitution pattern make it a valuable scaffold for designing novel chelating ligands and organocatalysts.

Basic Information

Product Name	5-Methyl-6-Cyclopropylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	2223040-70-6
Molecular Formula	C15H22BNO2
Molecular Weight	259.15 g/mol
Synonyms	5-Methyl-6-cyclopropylpyridine-3-boronic acid pinacol ester; (5-Methyl-6-cyclopropylpyridin-3-yl)boronic acid pinacol ester; 6-Cyclopropyl-5-methylpyridine-3-boronic acid pinacol ester; 3-Boronic acid, 5-methyl-6-cyclopropyl-, pinacol ester, pyridine derivative; Pinacol (5-methyl-6-cyclopropylpyridin-3-yl)boronate; B-(5-Methyl-6-cyclopropyl-3-pyridinyl)boronic acid pinacol ester; Boronic acid, B-(5-methyl-6-cyclopropyl-3-pyridinyl)-, pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Methyl-6-Cyclopropylpyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.