Description

2-(3-Chloro-5-Cyclopropylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis. CAS No. 2223036-52-8.

Application

This versatile boronic ester is a key reagent in various advanced chemical syntheses. Its primary and related applications include:

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific aryl-chloro and cyclopropyl motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry.
• Ligand and Catalyst Preparation: Can be utilized to synthesize novel ligands or functionalized catalysts for asymmetric synthesis.

Basic Information

Product Name	2-(3-Chloro-5-Cyclopropylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2223036-52-8
Molecular Formula	C15H20BClO2
Molecular Weight	278.58 g/mol
Synonyms	(3-Chloro-5-cyclopropylphenyl)boronic acid pinacol ester; 3-Chloro-5-cyclopropylbenzeneboronic acid pinacol ester; Pinacol (3-chloro-5-cyclopropylphenyl)boronate; (3-Chloro-5-cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(3-Chloro-5-cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-5-cyclopropylphenylboronic acid pinacol ester; B-(3-Chloro-5-cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 2-(3-Chloro-5-Cyclopropylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient air during use. Ideal storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.