Description

4-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole is a high-value organoboron building block, specifically a thiazole-substituted boronic ester, essential for modern cross-coupling reactions. Its core value lies in enabling the precise and efficient construction of complex heterocyclic molecules, which are pivotal in advanced material and pharmaceutical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel drug candidates, particularly those containing complex thiazole cores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific thiazole-based architectures.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where thiazole units modify electronic properties.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Academic & Industrial R&D: A fundamental reagent for method development and exploring new chemical spaces in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	4-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole
CAS No.	2223035-41-2
Molecular Formula	C11H18BNO2S
Molecular Weight	239.14 g/mol
Synonyms	4-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-ethylthiazole; 4-Ethyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; Thiazole, 4-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol 4-Ethylthiazole-5-boronate; 4-Ethylthiazole-5-boronic acid pinacol ester; CAS 2223035-41-2
EINECS	Contact for details

Quality Control

Every batch of 4-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive cross-coupling applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.