Description

3-Cyclopropylthiophene-2-Boronic Acid Pinacol Ester is a high-value organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by pharmaceutical R&D teams, agrochemical scientists, and advanced material researchers for the synthesis of novel active ingredients and functional molecules. Its unique cyclopropyl-thiophene scaffold offers significant potential for modulating the physicochemical properties of target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Serves as a precursor for organic electronic materials, such as semiconductors for OLEDs and OFETs.
• Ligand & Catalyst Development: Employed in the synthesis of novel ligands for transition metal catalysis.
• Chemical Biology Probes: Facilitates the creation of tagged molecules for studying biological pathways and target engagement.
• Scalable Process Chemistry: Suitable for use in pilot plant and commercial-scale API manufacturing under cGMP guidelines.

Basic Information

Product Name	3-Cyclopropylthiophene-2-Boronic Acid Pinacol Ester
CAS No.	2223033-79-0
Molecular Formula	C₁₃H₁₉BO₂S
Molecular Weight	250.16 g/mol
Synonyms	2-(3-Cyclopropylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Cyclopropylthiophene-2-boronic acid pinacol ester; 2-(3-Cyclopropyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Cyclopropyl-2-thiopheneboronic acid pinacol ester; (3-Cyclopropylthiophen-2-yl)boronic acid pinacol ester; Boronic acid, B-(3-cyclopropyl-2-thienyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 3-Cyclopropylthiophene-2-Boronic Acid Pinacol Ester is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistency for critical synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.