Description

5-Methyl-2-(cyclopropyl)thiazole-4-boronic acid pinacol ester is a high-value organoboron building block, specifically a boronic ester derivative, crucial for modern synthetic chemistry. Its primary value lies in enabling the Suzuki-Miyaura cross-coupling reaction, a powerful and widely used method for forming carbon-carbon bonds under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who are developing novel heterocyclic compounds, active pharmaceutical ingredients (APIs), and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those containing the thiazole and cyclopropyl pharmacophores prevalent in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and other functional organic compounds.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical coupling partner to introduce the 5-methyl-2-(cyclopropyl)thiazole moiety into complex molecular architectures.
• Chemical Library Development: Utilized in parallel and combinatorial synthesis for high-throughput screening to discover new bioactive molecules.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the efficient, large-scale production of target molecules.

Basic Information

Product Name	5-Methyl-2-(Cyclopropyl)Thiazole-4-Boronic Acid Pinacol Ester
CAS No.	2223033-43-8
Molecular Formula	C₁₃H₂₀BNO₂S
Molecular Weight	265.18 g/mol
Synonyms	5-Methyl-2-cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 2-Cyclopropyl-5-methylthiazole-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyclopropyl-5-methylthiazole; 2-Cyclopropyl-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; Boronic acid, B-[2-cyclopropyl-5-methyl-4-thiazolyl]-, 1,1-dimethylethyl ester; 5-Methyl-2-cyclopropylthiazole-4-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-(cyclopropyl)thiazole-4-boronic acid pinacol ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in GMP and ISO-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize exposure to ambient humidity. Ideal storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.