Description

6-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinonitrile is a high-value, multi-functional chemical building block, specifically a picolinonitrile derivative containing a boronic ester pinacol group. This compound is essential for facilitating efficient cross-coupling reactions, enabling the rapid synthesis of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis. The CAS number for this compound is 2223032-34-4.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific halogenated heterocyclic cores.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and enzyme inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic Research: A valuable tool in university and institutional labs for methodological development in organometallic and synthetic organic chemistry.

Basic Information

Product Name	6-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinonitrile
CAS No.	2223032-34-4
Molecular Formula	C₁₂H₁₄BClN₂O₂
Molecular Weight	264.51 g/mol
Synonyms	6-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-chloropicolinonitrile; 6-Chloro-4-(pinacolatoboron)picolinonitrile; 2-Chloro-4-cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-Chloro-4-(pinacolboronato)picolinonitrile; 6-Chloro-4-(pinacolboranyl)picolinonitrile; 6-Chloro-4-(pinacolato)boron-picolinonitrile
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize decomposition. Recommended storage temperature: 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.