Description

2-(3-Cyclopropyl-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals. The compound is supplied under strict quality control to ensure optimal performance and batch-to-batch consistency for demanding R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used to construct complex heterocyclic and fluorinated structures found in advanced herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged molecules and bioconjugates for proteomics and diagnostic assay development.
• Academic & Process R&D: A versatile reagent for methodology development and exploring new synthetic routes in academic and industrial laboratories.

Basic Information

Product Name	2-(3-Cyclopropyl-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2223032-03-7
Molecular Formula	C15H20BFO2
Molecular Weight	262.13 g/mol
Synonyms	(3-Cyclopropyl-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-3-cyclopropylphenylboronic acid pinacol ester; 3-Cyclopropyl-2-fluorobenzeneboronic acid pinacol ester; Pinacol (3-cyclopropyl-2-fluorophenyl)boronate; B-(3-Cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Fluoro-3-cyclopropylbenzeneboronic acid, pinacol ester; CAS 2223032-03-7
EINECS	Contact for details

Quality Control

Our 2-(3-Cyclopropyl-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and chemical identity suitable for sensitive cross-coupling applications. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.