Description

2-(3-Cyclopropyl-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile and stable intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing cyclopropyl and substituted biphenyl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the introduction of specific aryl groups is required.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: A reliable boron reagent for palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds under mild conditions.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for screening.
• Ligand and Catalyst Preparation: Useful in the synthesis of specialized ligands and organometallic catalysts.

Basic Information

Product Name	2-(3-Cyclopropyl-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2223031-05-6
Molecular Formula	C₁₆H₂₃BO₂
Molecular Weight	258.17 g/mol
Synonyms	(3-Cyclopropyl-4-methylphenyl)boronic acid pinacol ester; 3-Cyclopropyl-4-methylbenzeneboronic acid pinacol ester; (3-Cyclopropyl-4-methylphenyl)BPin; Pinacol (3-cyclopropyl-4-methylphenyl)boronate; 2-(3-Cyclopropyl-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Cyclopropyl-4-methylphenylboronic acid pinacol ester; Boronic acid, B-(3-cyclopropyl-4-methylphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-(3-Cyclopropyl-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.