Description

5-Cyclopropyl-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-purity, advanced pharmaceutical intermediate featuring a versatile aniline-boronic ester pinacol structure. This compound is a critical building block in modern synthetic chemistry, enabling efficient cross-coupling reactions for the construction of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic ester, essential for constructing biaryl motifs in drug candidates.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing cyclopropyl and aniline functional groups.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the unique cyclopropyl-aniline scaffold can impart specific biological activity.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors and light-emitting materials for electronic devices.
• Chemical Biology & Probe Synthesis: Useful for creating molecular probes and labeled compounds for biochemical and diagnostic research applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Cyclopropyl-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	2223029-55-6
Molecular Formula	C15H22BNO2
Molecular Weight	259.15 g/mol
Synonyms	[2-Amino-4-cyclopropylphenyl]boronic acid pinacol ester; 5-Cyclopropyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-cyclopropylaniline; 4-Cyclopropyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 5-Cyclopropyl-2-(pinacolboron)aniline; Boronic acid, B-[2-amino-4-cyclopropylphenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 5-Cyclopropyl-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Optimal storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.