Description

6-Chloro-5-Ethoxypyridine-3-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by pharmaceutical, agrochemical, and advanced materials research sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to construct heterocyclic cores for new-generation herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Catalyst & Ligand Development: Utilized in the synthesis of novel bidentate ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the life sciences industry.

Basic Information

Product Name	6-Chloro-5-Ethoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	2223029-21-6
Molecular Formula	C13H19BClNO3
Molecular Weight	283.56 g/mol
Synonyms	6-Chloro-5-ethoxypyridin-3-ylboronic acid pinacol ester; 5-Ethoxy-6-chloropyridine-3-boronic acid pinacol ester; (6-Chloro-5-ethoxypyridin-3-yl)boronic acid pinacol ester; 2-(6-Chloro-5-ethoxy-3-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 6-Chloro-5-ethoxy-3-pyridineboronic acid pinacol ester; Boronic acid, B-(6-chloro-5-ethoxy-3-pyridinyl)-, 1,1-dimethylethyl ester; CAS 2223029-21-6
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Every batch is characterized by NMR (1H, 13C), HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) with full analytical data are available upon request. We adhere to a cGMP-compliant quality management system for traceability and consistency, suitable for use in regulated pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.