Description

2，2'-(Cyclopropane-1，1-Diyl)Bis(4，4，5，5-Tetramethyl-1，3，2-Dioxaborolane) is a high-purity, bifunctional boronic ester building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional polymers.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical spiro-cyclopropyl precursor for introducing constrained, three-dimensional fragments into drug candidates to modulate their physicochemical and pharmacological properties.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of new active pharmaceutical ingredients (APIs), particularly for constructing sterically hindered, metabolically stable cores.
• Agrochemical Research: Employed in creating novel herbicides, fungicides, and insecticides where the cyclopropane moiety can enhance biological activity and environmental stability.
• Materials Science & OLED Development: Acts as a monomer or cross-linking agent in the synthesis of organic electronic materials, including polymers for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Probe Development: Utilized for synthesizing molecular probes and bioconjugates, leveraging the boronate functionality for selective labeling or as a handle for further modification.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic chemistry and for exploring new chemical spaces in discovery libraries.

Basic Information

Product Name	2，2'-(Cyclopropane-1，1-Diyl)Bis(4，4，5，5-Tetramethyl-1，3，2-Dioxaborolane)
CAS No.	2222867-16-3
Molecular Formula	C19H34B2O4
Molecular Weight	348.09 g/mol
Synonyms	1,1-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropane; Cyclopropane-1,1-diylbis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane); 1,1-Cyclopropanediyldimethylene Bis(boronic Acid), B,B-Bis(Pinacol Ester); Spirocyclopropane Bis(Pinacol Boronate); 1,1-Bis(Pinacolboronatemethyl)cyclopropane; 1,1-Bis(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ylmethyl)cyclopropane; 2222867-16-3
EINECS	Contact for details

Quality Control

Every batch of 2，2'-(Cyclopropane-1，1-Diyl)Bis(4，4，5，5-Tetramethyl-1，3，2-Dioxaborolane) undergoes rigorous analytical testing to ensure it meets the high standards required for sensitive synthetic applications. Our quality assurance protocols include identity confirmation, purity assessment, and impurity profiling using advanced techniques like NMR and HPLC. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.