Description

Methyl 4-(1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Cyclopropyl)Benzoate is a high-value, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is specifically designed for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for forming carbon-carbon bonds in complex molecule construction. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise and reliable boronic ester reagents. The cyclopropyl and benzoate functional groups offer unique steric and electronic properties for creating novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring cyclopropyl-aryl linkages.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Serves as a precursor for organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to introduce the functionalized cyclopropyl benzoate moiety into target molecules.
• Chemical Biology & Medicinal Chemistry: A valuable tool for creating molecular probes and optimizing the structure-activity relationships (SAR) of lead compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring specialized boronic esters.

Basic Information

Product Name	Methyl 4-(1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Cyclopropyl)Benzoate
CAS No.	2222866-66-0
Molecular Formula	C19H27BO4
Molecular Weight	330.23 g/mol
Synonyms	[4-(1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropyl)phenyl]methanoate; Methyl 4-[1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropyl]benzoate; 4-(1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropyl)benzoic acid methyl ester; Benzoic acid, 4-[1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropyl]-, methyl ester; Pinacol ester of [4-(1-boronic acid-cyclopropyl)benzoic acid methyl ester]; Cyclopropylphenyl boronic ester, pinacol protected; Advanced Suzuki coupling reagent.
EINECS	Contact for details

Quality Control

Our Methyl 4-(1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Cyclopropyl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H and ¹³C), and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.