Description

3-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Azetidine Hydrochloride is a specialized, high-value chemical building block featuring a reactive diazirine photoaffinity label. This compound is critical for advanced research and development in chemical biology and medicinal chemistry, enabling the study of biomolecular interactions and target identification. It is primarily utilized by pharmaceutical R&D teams, agrochemical innovators, and academic research institutions focused on photochemistry and probe development.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent cross-linking in target identification and binding site mapping studies for drug discovery.
• Chemical Biology Probes: Used to synthesize activity-based probes (ABPs) for profiling enzyme function and identifying novel therapeutic targets.
• Proteomics Research: Facilitates the study of protein-protein and protein-ligand interactions through photo-crosslinking methodologies.
• Medicinal Chemistry: Serves as a versatile intermediate for incorporating the trifluoromethyl-diazirine moiety into potential drug candidates to enhance binding studies.
• Agrochemical Research: Applied in the development of novel bioactive compounds and the study of their mode of action in plants and pests.
• Material Science: Potential use in the surface functionalization of polymers and other materials via photochemical grafting.

Basic Information

Product Name	3-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Azetidine Hydrochloride
CAS No.	2219371-87-4
Molecular Formula	C6H7ClF3N3
Molecular Weight	213.59 g/mol
Synonyms	3-(3-(Trifluoromethyl)-3H-diazirin-3-yl)azetidine hydrochloride; 3-(3-Trifluoromethyl-3H-diazirin-3-yl)azetidine HCl; Azetidine, 3-[3-(trifluoromethyl)-3H-diazirin-3-yl]-, hydrochloride; 3-(3-Trifluoromethyldiazirin-3-yl)azetidine hydrochloride; 3-(3-(Trifluoromethyl)diazirin-3-yl)azetidine hydrochloride; 3-(3-Trifluoromethyl-3H-diazirin-3-yl)azetidine hydrochloride; Photoaffinity Labeling Reagent 2219371-87-4; Trifluoromethyl Diazirine Azetidine HCl
EINECS	Contact for details

Quality Control

Our production of 3-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Azetidine Hydrochloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We maintain compliance with relevant quality management systems to support our global clientele in regulated and non-regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.