Description

2,4-Difluoro-3-Cyanophenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry where its unique difluoro-cyano-substituted aromatic boronic ester structure enables precise Suzuki-Miyaura cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating complex, fluorinated target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling Reagent: Used in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, essential for constructing biaryl structures in drug discovery and material science.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and pesticides that benefit from the properties of fluorine atoms.
• Liquid Crystal & OLED Material Research: Employed in the synthesis of fluorinated organic semiconductors and liquid crystal molecules for electronic displays.
• Chemical Biology & Probe Development: Useful for creating fluorescent tags and molecular probes for imaging and diagnostic applications.
• Polymer Chemistry: Acts as a monomer or chain extender in the synthesis of specialty polymers with tailored electronic or optical properties.

Basic Information

Product Name	2,4-Difluoro-3-Cyanophenylboronic Acid Pinacol Ester
CAS No.	2216724-47-7
Molecular Formula	C14H15BF2NO2
Molecular Weight	277.09 g/mol
Synonyms	2,4-Difluoro-3-cyanophenylboronic acid pinacol ester; (2,4-Difluoro-3-cyanophenyl)boronic acid pinacol ester; 2-(2,4-Difluoro-3-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Cyano-2,4-difluorophenylboronic acid pinacol ester; Pinacol (2,4-difluoro-3-cyanophenyl)boronate; Boronic acid, B-(2,4-difluoro-3-cyanophenyl)-, 1,1-dimethylethyl ester (9CI); CAS 2216724-47-7.
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Cyanophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.