Description

Ethyl 5-(2,2-Dimethyltetrahydro-2H-Pyran-4-Yl)-1H-Indole-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex indole-pyrone hybrid structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique indole core fused with a tetrahydropyran moiety.
• Process Development & Scale-up: Employed in the development and optimization of scalable synthetic routes for new APIs under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and the production of non-commercial, investigational compounds.
• Academic Research: Utilized in university and institutional labs for exploring new heterocyclic chemistry and developing novel synthetic methodologies.

Basic Information

Product Name	Ethyl 5-(2,2-Dimethyltetrahydro-2H-Pyran-4-Yl)-1H-Indole-2-Carboxylate
CAS No.	2212021-76-4
Molecular Formula	C18H23NO3
Molecular Weight	301.38 g/mol
Synonyms	Ethyl 5-(2,2-dimethyl-3,4-dihydro-2H-pyran-4-yl)-1H-indole-2-carboxylate; 1H-Indole-2-carboxylic acid, 5-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-, ethyl ester; 2212021-76-4; 5-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-1H-indole-2-carboxylic acid ethyl ester; Ethyl 5-(2,2-dimethyl-3,4-dihydro-2H-pyran-4-yl)indole-2-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 5-(2,2-Dimethyltetrahydro-2H-Pyran-4-Yl)-1H-Indole-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development projects with custom purity grades, from research (95%+) to GMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong bases and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.