Description

5-[3,5-Bis(Trifluoromethyl)Phenyl]-2-Furonitrile is a high-value, fluorinated aromatic nitrile building block of significant interest in advanced chemical synthesis. Its core value lies in the unique combination of a furan ring, a nitrile group, and two highly electron-withdrawing trifluoromethyl groups, which imparts exceptional reactivity and physicochemical properties. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by material scientists developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 groups enhance bioavailability and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of high-performance, fluorinated polymers and resins with enhanced chemical and thermal resistance.
• Liquid Crystal & OLED Materials: Employed in the design of fluorinated components for electronic display technologies and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Sonogashira) and as a precursor for heterocyclic compounds due to its versatile functional groups.
• Chemical Research & Development: A valuable tool for medicinal and process chemists in structure-activity relationship (SAR) studies and novel synthetic route exploration.

Basic Information

Product Name	5-[3,5-Bis(Trifluoromethyl)Phenyl]-2-Furonitrile
CAS No.	2197056-54-3
Molecular Formula	C13H5F6NO
Molecular Weight	305.18 g/mol
Synonyms	5-[3,5-Bis(trifluoromethyl)phenyl]furan-2-carbonitrile; 2-Cyano-5-[3,5-bis(trifluoromethyl)phenyl]furan; 3,5-Bis(trifluoromethyl)phenyl-2-furonitrile; 5-(3,5-Bis(trifluoromethyl)phenyl)-2-furancarbonitrile; 2-Furonitrile, 5-[3,5-bis(trifluoromethyl)phenyl]-; [3,5-Bis(trifluoromethyl)phenyl]-2-furonitrile
EINECS	Contact for details

Quality Control

Our 5-[3,5-Bis(Trifluoromethyl)Phenyl]-2-Furonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.