Description

1,3-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Bicyclo[1.1.1]Pentane is a highly functionalized, advanced organic building block featuring a rigid bicyclo[1.1.1]pentane (BCP) core symmetrically substituted with pinacol boronate ester groups. This compound is engineered to serve as a critical precursor in modern synthetic chemistry, enabling the efficient incorporation of the valuable BCP scaffold into complex molecular architectures. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug discovery, medicinal chemistry, and the synthesis of novel polymers.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fragment-based drug discovery and for creating three-dimensional, sp3-rich bioisosteres to improve drug-like properties.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the efficient, palladium-catalyzed introduction of the rigid bicyclo[1.1.1]pentane unit into complex molecules, a valuable transformation for medicinal chemistry.
• Agrochemical Research: Used in the development of new crop protection agents with potentially enhanced stability and bioavailability.
• Advanced Materials Synthesis: Serves as a monomer or cross-linker for creating polymers with unique mechanical, thermal, or optical properties due to the rigid BCP core.
• Chemical Biology Probes: Facilitates the creation of molecular probes and tools for studying biological systems and protein-ligand interactions.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing novel ligands and organometallic catalysts.

Basic Information

Product Name	1,3-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Bicyclo[1.1.1]Pentane
CAS No.	2195389-90-1
Molecular Formula	C20H34B2O4
Molecular Weight	360.10 g/mol
Synonyms	1,3-Bis(pinacolboronyl)bicyclo[1.1.1]pentane; 1,3-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)bicyclo[1.1.1]pentane; 1,3-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentacyclo[1.1.1.11,3.01,3]pentane; BCP(Bpin)2; 1,3-Bis-Bpin-BCP; 1,3-Diborylbicyclo[1.1.1]pentane pinacol ester
EINECS	Contact for details

Quality Control

Our 1,3-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Bicyclo[1.1.1]Pentane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 11B) and HPLC analysis, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, storage at 2-8°C is recommended. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%
NMR Purity (1H NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.