Description

4-Chloro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(2,2,2-Trifluoroethyl)-1H-Indazol-3-Amine is a high-value, multifunctional chemical building block designed for advanced synthesis. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern organic and medicinal chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a precursor for organic electronic materials, such as OLEDs and semiconductors.
• Chemical Synthesis: Enables the efficient introduction of the indazole core and functional groups via palladium-catalyzed cross-coupling.
• Academic & R&D: Essential reagent for methodological development and exploring new chemical spaces in university and corporate laboratories.
• Ligand & Catalyst Development: Potential precursor for creating novel ligands used in asymmetric catalysis.

Basic Information

Product Name	4-Chloro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(2,2,2-Trifluoroethyl)-1H-Indazol-3-Amine
CAS No.	2189684-53-3
Molecular Formula	C₁₅H₁₈BClF₃N₃O₂
Molecular Weight	375.58 g/mol
Synonyms	4-Chloro-1-(2,2,2-trifluoroethyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-3-amine; 1-(2,2,2-Trifluoroethyl)-4-chloro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-3-amine; 4-Chloro-7-(pinacolatoboryl)-1-(2,2,2-trifluoroethyl)-1H-indazol-3-amine; 4-Chloro-7-boronic acid pinacol ester-1-(2,2,2-trifluoroethyl)-1H-indazol-3-amine; CAS 2189684-53-3
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(2,2,2-Trifluoroethyl)-1H-Indazol-3-Amine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.