Description

(R)-5-Fluoro-3-Methylisobenzofuran-1(3H)-One is a high-value chiral building block and pharmaceutical intermediate. This compound matters for its role in the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) where its specific stereochemistry and fluorine substitution are critical for biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material science industries. The product is supplied with a high level of purity and batch-to-batch consistency to meet stringent R&D and production requirements.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, especially in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the isobenzofuranone scaffold imparts specific biological properties.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in the development of new catalytic systems for stereoselective synthesis.
• Material Science Precursor: Potential building block for specialty polymers or organic electronic materials due to its fused aromatic structure.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms or biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	(R)-5-Fluoro-3-Methylisobenzofuran-1(3H)-One
CAS No.	2178118-85-7
Molecular Formula	C9H7FO2
Molecular Weight	166.15 g/mol
Synonyms	(R)-5-Fluoro-3-methylphthalide; (3R)-5-Fluoro-3-methyl-1,3-dihydro-2-benzofuran-1-one; (R)-5-Fluoro-3-methyl-1,3-dihydroisobenzofuran-1-one; (R)-5-Fluoro-3-methylphthalide; (R)-5-Fluoro-3-methyl-2-benzofuran-1(3H)-one; (3R)-5-Fluoro-3-methylphthalide; 5-Fluoro-3-methylisobenzofuran-1(3H)-one, (R)-; (R)-5-Fluoro-3-methylisobenzofuranone
EINECS	Contact for details

Quality Control

Our (R)-5-Fluoro-3-Methylisobenzofuran-1(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity, standard identity confirmation (IR, NMR), and quantification of organic impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, temperatures between 2°C and 8°C are recommended to maintain stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.