Description

1-(Difluoromethyl)-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, multi-functional heterocyclic building block containing both a pyrazole core and a protected boronic ester group. This compound is specifically engineered for advanced cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a key boron-containing coupling partner for the synthesis of biaryl and heteroaryl structures in drug discovery.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of new therapeutic agents, including kinase inhibitors and other small molecule drugs.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated system.
• Chemical Biology & Probe Development: Utilized for labeling and modifying biomolecules or creating activity-based probes for target identification.
• Process Chemistry & Scale-up: Provides a reliable and scalable intermediate for optimizing synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	1-(Difluoromethyl)-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	2173194-53-9
Molecular Formula	C10H15BF2N2O2
Molecular Weight	244.05 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(difluoromethyl)-1H-pyrazole; 1-(Difluoromethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-(difluoromethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-(Difluoromethyl)pyrazole-3-boronic acid pinacol ester; 3-Pinacolatoboryl-1-(difluoromethyl)pyrazole
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.