Description

n-Fmoc-n-(3,3,3-Trifluoropropyl)Glycine is a specialized, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound is engineered to introduce the unique physicochemical properties of a trifluoropropyl side chain into peptide backbones, enhancing metabolic stability and modulating lipophilicity. It is an essential building block for medicinal chemists and researchers in pharmaceutical R&D, agrochemical development, and material science who require high-purity, custom-tailored intermediates for novel bioactive compound discovery.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled incorporation of fluorinated motifs into peptide sequences.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide-based drug candidates where the trifluoropropyl group improves target binding affinity, membrane permeability, and in vivo stability.
• Chemical Biology Probes: Serves as a precursor for labeled or modified peptides used in studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Employed in the development of novel, fluorinated peptide mimetics with potential as bioactive agents in crop protection.
• Material Science: A building block for creating fluorinated polymers or supramolecular assemblies with tailored surface properties and stability.
• Custom Peptide Services: Supplied to CROs and CDMOs for the production of complex, non-standard peptides for client projects.

Basic Information

Product Name	n-Fmoc-n-(3,3,3-Trifluoropropyl)Glycine
CAS No.	2172448-56-3
Molecular Formula	C₂₁H₂₀F₃NO₄
Molecular Weight	407.38 g/mol
Synonyms	Fmoc-N-(3,3,3-trifluoropropyl)glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(3,3,3-trifluoropropyl)glycine; (2-(((9H-Fluoren-9-yl)methoxy)carbonyl)(3,3,3-trifluoropropyl)amino)acetic acid; N-Fmoc-N-(3,3,3-trifluoropropyl)glycine; Fmoc-Tfpg-OH; Fmoc-3,3,3-trifluoropropyl-glycine; N-[(9-Fluorenylmethoxy)carbonyl]-N-(3,3,3-trifluoropropyl)glycine
EINECS	Contact for details

Quality Control

Our n-Fmoc-n-(3,3,3-Trifluoropropyl)Glycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.