Description

1,3,3-Trifluorocyclobutane-1-Carboxylic Acid is a high-value, fluorinated cyclobutane derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a strained cyclobutane ring and a trifluoromethyl group, makes it an essential precursor for developing novel compounds with tailored properties. This intermediate is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to incorporate fluorinated motifs to enhance metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated cyclobutane scaffolds to modulate biological activity and pharmacokinetics.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides where the fluorinated cyclobutane structure can improve efficacy and environmental profile.
• Material Science: Serves as a monomer or precursor for specialty polymers and advanced materials, including liquid crystals and organic electronic components.
• Organic Synthesis Reagent: Employed in medicinal chemistry and process R&D for constructing complex molecules via reactions at the carboxylic acid group or the fluorinated ring system.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on the synthesis and reactivity of strained, fluorinated carbocycles.

Basic Information

Product Name	1,3,3-Trifluorocyclobutane-1-Carboxylic Acid
CAS No.	2168983-35-3
Molecular Formula	C5H5F3O2
Molecular Weight	158.09 g/mol
Synonyms	1,3,3-Trifluorocyclobutanecarboxylic Acid; 1-Carboxy-1,3,3-trifluorocyclobutane; 1,3,3-Trifluorocyclobutyl-1-carboxylic Acid; 1,1,3-Trifluorocyclobutane-1-carboxylic Acid; 1,3,3-Trifluorocyclobutane Carboxylic Acid; Cyclobutane-1-carboxylic acid, 1,3,3-trifluoro-; 2168983-35-3
EINECS	Contact for details

Quality Control

Our 1,3,3-Trifluorocyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.