Description

Ethanol, 2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]-, 1-methanesulfonate is a specialized bifunctional PEG derivative featuring a bromoalkyl group and a methanesulfonate (mesylate) ester. This compound is engineered as a high-value chemical intermediate, offering two distinct reactive handles for sequential conjugation and linker formation in advanced synthesis. It is primarily utilized by researchers and process chemists in the pharmaceutical and bioconjugation sectors who require precise, modular building blocks for constructing complex molecules, drug-linker systems, and functionalized materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of Antibody-Drug Conjugates (ADCs) and other targeted therapeutics, where its dual functionality allows for controlled linker assembly.
• Bioconjugation Reagent: Used to functionalize proteins, peptides, and oligonucleotides by reacting the bromo and mesylate groups with nucleophilic sites like thiols or amines.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the synthesis of functionalized polyethylene glycol (PEG) polymers and hydrogels with tailored properties.
• Material Science: Employed in surface modification and the creation of self-assembled monolayers (SAMs) to alter surface properties for biomedical devices.
• Prodrug Synthesis: Facilitates the development of prodrugs by acting as a cleavable linker between an active drug molecule and a targeting moiety.
• Chemical Biology Probes: Used to create labeled probes and tools for studying biological processes and interactions.

Basic Information

Product Name	Ethanol, 2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]-, 1-methanesulfonate
CAS No.	2167807-41-0
Molecular Formula	C11H23BrO7S
Molecular Weight	379.27 g/mol
Synonyms	2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethyl methanesulfonate; Br-PEG3-OMs; 1-Bromo-11-methanesulfonyl-3,6,9-trioxaundecane; 3,6,9-Trioxa-1-bromoundecan-11-yl methanesulfonate; 11-Bromo-3,6,9-trioxaundecyl methanesulfonate; Bromo-PEG3-mesylate; (2-Bromoethoxy)tri(ethylene glycol) methanesulfonate; PEG3 bromide mesylate
EINECS	Contact for details

Quality Control

Every batch of our Ethanol, 2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]-, 1-methanesulfonate is manufactured and tested under strict quality management systems. We ensure high purity and consistency through comprehensive analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your R&D and cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.