Description

3,3-Difluoro-1-(Trifluoromethyl)Cyclobutane-1-Carboxylic Acid is a high-value, multi-fluorinated cyclobutane building block essential for advanced organic synthesis. Its unique structure, featuring a carboxylic acid group on a highly fluorinated cyclobutane ring, makes it a critical intermediate for introducing sterically constrained, lipophilic motifs. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting GPCRs, kinases, and enzymes where fluorinated motifs are advantageous.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve compound stability and membrane permeability.
• Material Science Research: Serves as a precursor for specialty monomers and polymers, contributing to the development of advanced materials with specific chemical resistance or surface properties.
• Ligand and Catalyst Development: Employed in the synthesis of complex, fluorinated ligands for catalysis and molecular recognition applications.
• Fluorine Chemistry & SAR Studies: An important tool for structure-activity relationship (SAR) studies in drug discovery to investigate the effects of strategic fluorine substitution.

Basic Information

Product Name	3,3-Difluoro-1-(Trifluoromethyl)Cyclobutane-1-Carboxylic Acid
CAS No.	2167095-52-3
Molecular Formula	C7H5F5O2
Molecular Weight	216.11 g/mol
Synonyms	1-(Trifluoromethyl)-3,3-difluorocyclobutane-1-carboxylic acid; 3,3-Difluoro-1-(trifluoromethyl)cyclobutane-1-carboxylic acid; 1-Carboxy-3,3-difluoro-1-trifluoromethylcyclobutane; Cyclobutane-1-carboxylic acid, 3,3-difluoro-1-(trifluoromethyl)-; 2167095-52-3; FC-COOH Cyclobutane Derivative; Multi-fluorinated Cyclobutyl Acid
EINECS	Contact for details

Quality Control

Our production of 3,3-Difluoro-1-(Trifluoromethyl)Cyclobutane-1-Carboxylic Acid adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, handle with appropriate engineering controls and personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.