Description

1-Bromo-2-(1,1-Difluoroethyl)-4-Fluorobenzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines bromine, fluorine, and a difluoroethyl group to enable precise structural modifications in target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers and liquid crystals with tailored electronic or optical properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on molecular conformation, lipophilicity, and metabolic stability in medicinal chemistry.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Bromo-2-(1,1-Difluoroethyl)-4-Fluorobenzene
CAS No.	2166995-60-2
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	2-Bromo-1-(1,1-difluoroethyl)-4-fluorobenzene; 4-Fluoro-2-(1,1-difluoroethyl)bromobenzene; 1-Bromo-2-(1,1-difluoroethyl)-4-fluoro-benzene; Benzene, 1-bromo-2-(1,1-difluoroethyl)-4-fluoro-; 2166995-60-2; 2-(1,1-Difluoroethyl)-4-fluorobromobenzene; 4-Fluoro-α,α-difluoroethylbromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(1,1-Difluoroethyl)-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.