Description

1-o-Acetyl-3,5-Di-o-Benzoyl-2-Deoxy-D-Ribofuranose is a high-purity, protected ribofuranose derivative, a critical building block in nucleoside and oligonucleotide synthesis. Its value lies in providing precise stereochemical control and functional group protection, enabling the efficient and scalable production of complex biomolecules. This compound is essential for research and manufacturing in the pharmaceutical industry, particularly for developers of antiviral agents, anticancer drugs, and mRNA-based therapeutics.

Application

• Nucleoside Analog Synthesis: A key chiral intermediate for constructing modified nucleosides used in antiviral and anticancer pharmaceuticals.
• Oligonucleotide Manufacturing: Serves as a protected phosphoramidite precursor for solid-phase synthesis of DNA/RNA oligonucleotides for research, diagnostics, and therapeutics.
• Prodrug Development: Used in the design and synthesis of prodrugs to enhance the bioavailability and targeting of nucleoside-based active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Provides a reactive sugar scaffold for linking therapeutic payloads to antibodies, peptides, or other targeting molecules.
• Carbohydrate Chemistry Research: A valuable reagent for academic and industrial research exploring novel glycosylation methods and carbohydrate-based drug discovery.
• mRNA Vaccine & Therapeutic Components: Potential use in the synthesis of cap analogs or modified nucleotides to improve the stability and efficacy of mRNA products.

Basic Information

Item	Details
Product Name	1-o-Acetyl-3,5-Di-o-Benzoyl-2-Deoxy-D-Ribofuranose
CAS No.	2155800-38-5
Molecular Formula	C23H22O7
Molecular Weight	410.42 g/mol
Synonyms	1-O-Acetyl-3,5-di-O-benzoyl-2-deoxy-D-ribofuranose; 2-Deoxy-1-O-acetyl-3,5-di-O-benzoyl-D-ribofuranose; 1-Acetyl-3,5-dibenzoyl-2-deoxy-D-ribofuranose; 2-Deoxy-D-ribofuranose 1-acetate 3,5-dibenzoate; Protected 2-Deoxyribose Derivative; 2'-Deoxyribofuranose Intermediate
EINECS	Contact for details

Quality Control

Our 1-o-Acetyl-3,5-Di-o-Benzoyl-2-Deoxy-D-Ribofuranose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the exacting standards required for pharmaceutical synthesis. Certificates of Analysis (COA) with full traceability are provided to guarantee consistency, purity, and compliance with your research or cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.