Description

2,6-Bis(Benzyloxy)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, functionalized pyridine derivative containing a pinacol boronate ester group. This compound is a critical advanced pharmaceutical intermediate and versatile building block for modern synthetic chemistry, enabling the formation of carbon-carbon and carbon-heteroatom bonds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of complex molecules and active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key boronic ester reagent for constructing biaryl and heteroaryl structures prevalent in drug discovery.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based architectures.
• Ligand and Catalyst Development: Employed in the preparation of novel nitrogen-containing ligands for transition metal catalysis.
• Materials Science Research: A precursor for organic electronic materials, such as those used in OLEDs and organic semiconductors, where conjugated pyridine systems are valuable.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological processes and target engagement.

Basic Information

Product Name	2,6-Bis(Benzyloxy)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	2152673-80-6
Molecular Formula	C29H34BNO4
Molecular Weight	471.40 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-bis(phenylmethoxy)pyridine; 2,6-Di-O-benzyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2,6-Bis(benzyloxy)-3-(pinacolboron)pyridine; 3-Pyridineboronic acid, 2,6-bis(phenylmethoxy)-, pinacol ester; Pinacol 2,6-bis(benzyloxy)pyridin-3-ylboronate; 2,6-Dibenzyloxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Boronic acid, B-[2,6-bis(phenylmethoxy)-3-pyridinyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2,6-Bis(Benzyloxy)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.