Description

2-Methoxycarbonyl-3,4-Dihydro-2H-Benzopyran-6-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate belonging to the class of benzopyran boronic esters. This compound is a critical building block in modern synthetic organic chemistry, enabling the precise construction of complex molecular architectures through cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds, essential for constructing biaryl and heterobiaryl structures in medicinal chemistry.
• Organic Synthesis Research: Used in academic and industrial R&D labs for developing new synthetic methodologies and exploring novel chemical spaces.
• Ligand and Catalyst Development: Employed as a building block for creating novel ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and functional polymers requiring specific benzopyran motifs.

Basic Information

Product Name	2-Methoxycarbonyl-3,4-Dihydro-2H-Benzopyran-6-Boronic Acid Pinacol Ester
CAS No.	2152654-65-2
Molecular Formula	C17H23BO5
Molecular Weight	318.18 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-chromene-2-carboxylic acid methyl ester; Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-chromene-2-carboxylate; 2H-1-Benzopyran-6-boronic acid, 3,4-dihydro-2-methoxycarbonyl-, pinacol ester; Benzopyran boronic ester intermediate; Chromane boronic ester derivative
EINECS	Contact for details

Quality Control

Every batch of 2-Methoxycarbonyl-3,4-Dihydro-2H-Benzopyran-6-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full batch traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.