Description

2-(4,4-Difluorocyclohexyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. Its value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for synthesizing novel active ingredients and functional molecules. The CAS number for this material is 2152645-00-4.

Application

• Pharmaceutical Intermediate Synthesis: A key precursor in the development of active pharmaceutical ingredients (APIs), particularly for candidates containing difluorocyclohexyl motifs.
• Agrochemical Research: Used to construct novel herbicide and pesticide molecules through efficient cross-coupling strategies.
• Material Science: Serves as a building block for creating organic electronic materials, liquid crystals, and polymers with specific fluorinated properties.
• Medicinal Chemistry: Enables rapid parallel synthesis and library generation for structure-activity relationship (SAR) studies in drug discovery programs.
• Process Chemistry: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Chemical Biology: Utilized as a probe or linker in bioconjugation chemistry due to its selective reactivity.

Basic Information

Product Name	2-(4,4-Difluorocyclohexyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2152645-00-4
Molecular Formula	C₁₂H₂₁B₁F₂O₂
Molecular Weight	246.11 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(4,4-difluorocyclohexyl)-1,3,2-dioxaborolane; (4,4-Difluorocyclohexyl)boronic acid pinacol ester; 2-(4,4-Difluorocyclohexyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4-Difluorocyclohexaneboronic acid pinacol ester; Pinacol (4,4-difluorocyclohexyl)boronate; (4,4-Difluorocyclohexyl)-Bpin; DifluorocyclohexylBPin
EINECS	Contact for details

Quality Control

Our 2-(4,4-Difluorocyclohexyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and consistent performance for critical cross-coupling applications. Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.