Description

Cyclohexanol, 4-Amino-1-(Trifluoromethyl)-, Hydrochloride (1:1),trans- is a high-purity, functionalized cyclohexanol derivative of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of an amino group and a trifluoromethyl group on the cyclohexane backbone, making it a versatile chiral building block for the development of novel bioactive molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the creation of new drug candidates and crop protection agents with enhanced properties.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve compound stability, lipophilicity, and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis to produce enantiomerically pure compounds.
• Material Science Research: Investigated as a monomer or functional additive in the synthesis of specialty polymers and advanced materials with unique surface properties or optical characteristics.
• Chemical Biology Probe Synthesis: Employed in the design and synthesis of molecular probes for studying biological pathways and protein-ligand interactions.

Basic Information

Product Name	Cyclohexanol, 4-Amino-1-(Trifluoromethyl)-, Hydrochloride (1:1),trans-
CAS No.	2137056-98-3
Molecular Formula	C7H11F3NO • HCl
Molecular Weight	217.62 g/mol (Free base) / 254.08 g/mol (Hydrochloride salt)
Synonyms	trans-4-Amino-α,α,α-trifluoromethylcyclohexanemethanol Hydrochloride; (1r,4r)-4-Amino-α,α,α-trifluoromethylcyclohexanemethanol Hydrochloride; 4-Amino-1-(trifluoromethyl)cyclohexanol Hydrochloride, trans-; 4-Amino-α,α,α-trifluoromethylcyclohexanemethanol HCl, trans-; (trans)-4-Amino-α,α,α-trifluoromethyl-1-cyclohexanemethanol Hydrochloride; 1-(Trifluoromethyl)-4-aminocyclohexanol Hydrochloride, trans-
EINECS	Contact for details

Quality Control

Our Cyclohexanol, 4-Amino-1-(Trifluoromethyl)-, Hydrochloride (1:1),trans- is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.