Description

Cyclopropanecarboxylic Acid, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester, (1R,2S)-Rel- CAS NO 2135443-14-8 is a high-purity, stereodefined boronic ester building block essential for modern synthetic chemistry. This compound is a critical chiral intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research and development chemists and process development teams for applications in Suzuki-Miyaura cross-coupling reactions and other advanced synthetic methodologies.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing cyclopropane motifs.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where the cyclopropane ring confers specific biological activity.
• Material Science: Serves as a precursor for functionalized polymers and advanced organic materials requiring precise stereochemistry.
• Suzuki-Miyaura Cross-Coupling: The boronic ester functional group makes it an ideal partner for palladium-catalyzed cross-coupling to form new carbon-carbon bonds with high stereochemical fidelity.
• Asymmetric Synthesis: Utilized in the construction of complex, enantiomerically pure molecules for medicinal chemistry and catalysis research.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological systems.

Basic Information

Item	Detail
Product Name	Cyclopropanecarboxylic Acid, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester, (1R,2S)-Rel-
CAS No.	2135443-14-8
Molecular Formula	C₁₂H₂₁BO₄
Molecular Weight	240.11 g/mol
Synonyms	(1R,2S)-rel-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropanecarboxylic acid ethyl ester; Ethyl (1R,2S)-rel-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropanecarboxylate; rel-(1R,2S)-Ethyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropanecarboxylate; Chiral Cyclopropane Boronic Ester; B-cyclopropylboronic acid pinacol ester derivative; Ethyl 2-(pinacolatoboryl)cyclopropanecarboxylate (rel-(1R,2S)-); (1R,2S)-Cyclopropaneboronic acid, 2-(ethoxycarbonyl)-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and enantiomeric excess meet the stringent requirements of our clients. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.